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Breaking down cancer's defense for future vaccines

Researchers at the EPFL have identified an important mechanism that could lead to the design of more effective cancer vaccines. Their discovery of a new-found role of the lymphatic system in tumour...

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Genetically modified mice to visualize in vivo inflammation and metastasis

One of the major routes of tumor cell dissemination to form metastasis at distant organs in the body is the lymphatic system. To study this process, still poorly understood, and to gain information on...

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Putting pressure on lymphoedema

(Medical Xpress) -- Researchers from Flinders University are trialling a new treatment for lymphoedema of the legs, giving fresh hope to sufferers of the disabling condition.

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Boost your immune system with a healthy lifestyle

Your immune system is your defense against disease. Its many different parts need to work in balance and harmony to protect our bodies from harmful germs and viruses; in essence to attack and destroy...

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Obesity may raise odds for painful leg condition

(HealthDay) -- The health risks associated with being overweight and obese are well publicized, but new research may add another condition to this list: leg lymphedema, pain and swelling due to...

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Blood test could lead to improved diagnosis and treatment of breast cancer

Scientists have discovered that a simple blood test could lead to better diagnosis and treatment for early-stage breast cancer patients, according to an Article published Online First in The Lancet...

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Laser-light testing of breast tumor fiber patterns helps show whose cancer is...

Using advanced microscopes equipped with tissue-penetrating laser light, cancer imaging experts at Johns Hopkins have developed a promising, new way to accurately analyze the distinctive patterns of...

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New insight into RASopathy-associated lymphatic defects

The RAS pathway is a cellular signaling pathway that regulates growth and development in humans. RASopathies are a group of diseases characterized by defects in RAS signaling.

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Lymphatic vasculature: A cholesterol removal system

Reverse cholesterol transport is a process in which accumulated cholesterol is removed from tissues, including the artery wall, and transported back to the liver for excretion. Little is known about...

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Transcription factors regulating blood oxygen linked to melanoma metastases

Researchers at the University of North Carolina have discovered that transcription factors regulating the levels of oxygen in the blood also play a role in the spread of the skin cancer melanoma.

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Genetic markers linked to the development of lymphedema in breast cancer...

A new UCSF study has found a clear association between certain genes and the development of lymphedema, a painful and chronic condition that often occurs after breast cancer surgery and some other...

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Photoacoustics spares healthy lymph nodes in patients with metastasized cancer

If a tumour has spread through the lymph nodes, the decision is often taken to exercise caution and remove extra tissue, to prevent it from spreading further. This often involves the removal of healthy...

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Lymphatic fluid takes detour

When tumours metastasise, they can block lymphatic vessels, as researchers from ETH Zurich have discovered using a new method. The lymphatic fluid subsequently has to find a new path through the...

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Study supports role for skin sodium in blood pressure regulation

It's time to expand the models for blood pressure regulation, according to clinical pharmacologist Jens Titze, M.D. Titze and his colleagues have identified a new cast of cells and molecules that...

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Brain's 'garbage truck' may hold key to treating Alzheimer's and other disorders

In a perspective piece appearing today in the journal Science, researchers at University of Rochester Medical Center (URMC) point to a newly discovered system by which the brain removes waste as a...

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To sleep, perchance to clean: Study reveals brain 'takes out the trash' while...

In findings that give fresh meaning to the old adage that a good night's sleep clears the mind, a new study shows that a recently discovered system that flushes waste from the brain is primarily active...

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Anti-cancer lymphatic drugs show potential

Researchers at the University of Auckland are using zebrafish embryos to investigate potential medicines that will inhibit the spread of some cancers via the lymphatic system.

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New treatment resolves a hazardous airway complication in child with heart...

A case study published recently in the journal Pediatrics describes an innovative, minimally invasive procedure that treated plastic bronchitis, a potentially life-threatening disease, in a...

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Origins of left-sided gut artery, lymphatic system discovered

Researchers have understood very little about how blood and lymphatic vessels form in the mammalian gut – until now.

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The origin of the lymphatic vasculature uncovered

In a new study, published in Cell Reports, researchers at Uppsala University describe a novel mechanism by which lymphatic vessels form during embryonic development. The finding may open new...

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How cancer tricks the lymphatic system into spreading tumors

Swollen lymph nodes are often the earliest sign of metastatic spread of cancer cells. Now cancer researchers and immunologists at Sweden's Karolinska Institutet have discovered how cancer cells can...

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Lymphatic cells grown in the lab for the first time

For over one hundred years, scientists have debated the question of the origins of the lymphatic system - a parallel system to the blood vessels that serves as a conduit for everything from immune...

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Missing link found between brain, immune system

In a stunning discovery that overturns decades of textbook teaching, researchers at the University of Virginia School of Medicine have determined that the brain is directly connected to the immune...

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Study: Statins may stem tumor growth

(Medical Xpress)—One of the world's top selling drugs potentially also acts against the growth of new lymphatic vessels, with potential implications for cancer therapy. This surprising finding was...

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New study confirms immune cells are guided by gradients

(Medical Xpress)—A group of researchers in Austria and Switzerland has for the first time proven that immune cells migrate along chemical concentration gradients. This process has long been assumed but...

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New function for a messenger molecule

ETH Zurich Assistant Professor Cornelia Halin and her colleagues have discovered a new function of the well-known messenger protein interleukin-7: it facilitates the drainage of lymph fluid from...

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Researchers describe regulatory protein controlling the patterning of the...

The lymphatic vasculature is vital for the function of the immune system, but its development is poorly understood in comparison to that of the blood vasculature from which it arises. The vessels that...

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Flow means 'go' for proper lymph system development

The lymphatic system provides a slow flow of fluid from our organs and tissues into the bloodstream. It returns fluid and proteins that leak from blood vessels, provides passage for immune and...

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An invisible system to rescue the heart

Heart failure affects over one million people in France. Although the blood system is the first to have been explored for the purpose of improving heart function, a study by Inserm has revealed the...

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Blocking the migration of cancer cells to destroy them

Lymphoma is a cancer that affects lymphocytes, a type of white blood cell. The disease originates in a lymphoid organ (lymph node, spleen, or bone marrow) before spreading through the blood to...

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